Liquid resuscitation combined with hydrogen inhalation reduce acute kidney injury during septic shock in rats / 中国病理生理杂志
Chinese Journal of Pathophysiology
;
(12): 1703-1707,1728, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-660470
ABSTRACT
AIM:
To investigate the therapeutic effects of a novel fluid resuscitation protocol (early fluid resuscitation plus 2% hydrogen inhalation) on acute kidney injury during septic shock induced by lipopolysaccharide (LPS) in rats.METHODS:
Male Wistar rats were randomly divided into 4 groups (15 rats per group)control group,septic shock group,septic shock with early fluid resuscitation group (fluid group) and septic shock with early fluid resuscitation plus 2% hydrogen inhalation group (fluid + H2 group).The rats were ventilated,and a 2% hydrogen mixture was used in fluid + H2 group.LPS (10 mg/kg) was administered to establish the septic shock model in rats and fluid resuscitation was performed in fluid group and fluid + H2 group.RESULTS:
Fluid resuscitation with 2% hydrogen inhalation decreased the levels of serum creatinine,blood urea nitrogen and neutrophil gelatinase-associated lipocalin.It also reduced oxidative stress injury and decreased renal tumor necrosis factor-α and interleukin-6 levels compared with fluid resuscitation alone.CONCLUSION:
Early fluid resuscitation plus 2% hydrogen inhalation provided more protection against acute kidney injury during septic shock.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Practice guideline
/
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Pathophysiology
Year:
2017
Type:
Article
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