Secondary Amyloidosis in Patient with Spinal Cord Injury: Renal and Thyroid Amyloidosis / 대한신장학회잡지

ABSTRACT

Amyloidosis is an acquired or inherited disorder with protein folding and degradation characterizing the deposition of the proteinaceous material in the extracellular matrix of one or several organs. Secondary amyloidosis resulting from the deposition of serum amyloid A protein, occurs 1-5% during the lifetime of patients with chronic inflammatory disorders such as rheumatoid arthritis and ankylosing spondylitis. In addition, chronic pyelonephritis and pressure sores in patient with spinal cord injury are documented as risk factors of secondary amyloidosis. Thus, the efforts to treat and prevent the development of secondary amyloidosis and to preserve the renal function should focus on avoiding the chronic inflammatory state and a pathologic study of doubtful organs for early diagnosis should be performed. We have experienced one case of secondary amyloidosis in patient with spinal cord injury which involves with kidney and thyroid gland.