Influence of preoperative intensive atorvastatin therapy on no-reflow and cardiac function after selective PCI / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of preoperative intensive atorvastatin therapy on no-reflow and cardiac function after selective percutaneous coronary intervention (PCI).Methods:A total of 96 selective PCI patients treated in our hospital from Feb 2015 to Feb 2016 were selected.According to complete random grouping method, patients were randomly and equally divided into normal dose group (received atorvastatin of normal dose)and inten-sive group (received intensive atorvastatin therapy).Corrected TIMI frame count (CTFC),left ventricular ejection fraction (LVEF),left ventricular end-systolic volume index (LVESVI),left ventricular end-diastolic volume index (LVEDVI)before and one month after PCI,incidence rate of no-reflow were observed and compared between two groups.Results:Compared with normal dose group on one month after PCI,there were significant reductions in CTFCs of right coronary artery [(36.96±5.48)vs.(29.87±6.03)],left anterior descending artery [(37.57± 6.31)vs.(30.25±5.74)],left circumflex artery [(37.01±6.04)vs.(26.52±5.73)],mean CTFC [(37.03± 6.21)vs.(29.24±6.02)],incidence rate of no-reflow (16.67% vs.4.17%),LVESVI [(37.23±10.49)ml/m2 vs.(30.46±11.53)ml/m2 ]and LVEDVI [(80.02±14.38)ml/m2 vs.(71.34±16.52)ml/m2 ],and significant rise in LVEF [(43.11±5.23)% vs.(47.37±7.57)%]in intensive group,P <0.05 or <0.01. Conclusion:Preop-erative intensive atorvastatin therapy can effectively reduce incidence rate of no reflow and improve cardiac function of patients after PCI,which is worth extending.