Effects and mechanism of Shexiang Baoxin Pills on insulin resistance in patients with coronary heart disease / 药物评价研究

ABSTRACT

Objective To investigate the effects and mechanism of Shexiang Baoxin Pills on insulin resistance (IR) in patients with coronary heart disease.Methods From January 2016 to March 2017,82 patients with coronary heart disease in The Second People's Hospital of Nanyang were selected as the research object.All the patients were divided into observation group and control group with 41 cases in each group according to the principle of random envelope drawing.The control group was given conventional treatment,and the observation group was treated with Shexiang Baoxin Pills on the basis of the treatment of the control group.The observation periods of the two groups were 3 months.Results The total effective rates of the observation group and control group were 97.6％ and 82.9％,respectively,and the observation group was better than that of the control group (P ＜ 0.05).The IR indexes of the observation group and control group after treatment were (1.79 ± 0.45) and (2.44 ± 0.51),respectively,which were significantly lower than before treatment of (4.01 ± 0.44) and (4.00 ± 0.56) (P ＜ 0.05),and the IR index in the observation group after treatment was significantly higher than that in the control group (P ＜ 0.05).The serum CRP levels of the observation group and control group were significantly lower than those before treatment (P ＜ 0.05),and the level of serum CRP in the observation group after treatment was also significantly lower than that in the control group (P ＜ 0.05).Atter treatment,the coronary artery remodeling,no reconstruction and negative reconstruction in the observation group were 4 cases,25 cases and 13 cases,while the control group were 15 cases,10 cases and 16 cases,the difference between the two groups was statistically significant (P ＜ 0.05).Conclusion Shexiang Baoxin Pill can improve the therapeutic effect and improve the IR status in patients with coronary heart disease,and its mechanism may be related to inhibiting the expression of inflammatory factors and improving coronary artery remodeling.