Efficacy Observation of Alteplase Combined with Butylphthalide in the Treatment of Acute Ischemic Stroke / 中国药师

ABSTRACT

Objective:To observe the clinical efficacy and safety of alteplase combined with butylphthalide in the patients with a-cute ischemic stroke. Methods:Totally 108 cases of acute ischemic stroke patients in our hospital were selected and randomly divided into the experimental group and the control group with 54 ones in each. The two groups were both given such treatments as blood sugar control, blood lipid control, blood pressure control and the other conventional treatment, and the control group was given alteplase for thrombolysis treatment additionally, while the experimental group was given butylphthalide sodium chloride injection combined with al-teplase additionally. Both groups were treated for 14 days. The clinical effect, NIHSS score, daily life ability score and the adverse re-actions in the two groups were observed and compared. Results: The total effective rate in the experimental group was 94. 4%, and that was 81. 5% in the control group, and the difference was statistically significant (P<0. 05). The NIHSS score was reduced signifi-cantly(P<0. 05),and the life ability based on Barthel index score increased significantly (P<0. 05) in the two group after the 7-and 14-day treatment,and the improvement of the experimental group was significantly better than that of the control group with statistically significant differences (P<0. 05). There was no significant difference in the incidence of cerebral hemorrhage and the total adverse re-actions between the groups (P > 0.05). Conclusion: In the treatment of acute ischemic stroke, alteplase combined with bu-tylphthalide is safe and effective, and can effectively improve the neurological function and the ability of daily life, which is worthy of clinical application.