Relationship between highly sensitive cardiac troponin T and sepsis and outcome in critically ill patients / 中华内科杂志

ABSTRACT

Objective To investigate the prognostic value of highly sensitive cardiac Troponin T (hs-cTn T) for sepsis in critically ill patients.Methods Patients estimated to stay in the ICU of Fuxing Hospital for more than 24h were enrolled at from March 2014 to December 2014.Serum hs-cTn T was tested within two hours.Univariate and multivariate linear regression analyses were used to determine the association of variables with the hs-cTn T.Multivariable logistic regression analysis was used to evaluate the risk factors of 28-day mortality.Results A total of 125 patients were finally enrolled including 68 patients with sepsis and 57 without.The levels of hs-cTn T in sepsis and non-sepsis groups were significantly different[52.0(32.5,87.5) ng/L vs 14.0(6.5,29.0) ng/L respectively,P ＜0.001].In sepsis group,hs-cTn T among common sepsis,severe sepsis and septic shock were similar.Hs-cTn T was significantly higher in non-survivors than survivors [27 (13,52) ng/L vs 44.5 (28.8,83.5) ng/L,P ＜ 0.001].Age,sepsis,serum creatinine were independent risk factors affecting hs-cTn T by multivariate linear regression analyses.But hs-cTn T was not a risk factor for death.Conclusion Patients with sepsis had higher serum hs-cTn T than those without sepsis.but it was not found to be associated with the severity of sepsis.