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Amyotrophic lateral sclerosis-associated gene mutations and ALS animal models / 中国比较医学杂志
Chinese Journal of Comparative Medicine ; (6): 89-95, 2017.
Article in Chinese | WPRIM | ID: wpr-660920
ABSTRACT
Amyotrophic lateral sclerosis ( ALS ) is a progressive neurodegenerative disease characterized by a selective loss of upper and lower motor neurons that lead to paralysis and even death. Mutations in a large number of genes, including FUS/TLS, EPHA4, SS18 L1, ATXN2 and C9ORF72, are identified to the casual genes of ALS, which broadens our understanding of the role of RNA modulation in ALS pathogenesis. This review summarized ALS-associated genes and the related ALS rodent models.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Comparative Medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Comparative Medicine Year: 2017 Type: Article