Clinical efficacy of Liuweidihuang Pill combined with Metformin in treatment of type 2 diabetes with Qi-Yin deficiency / 药物评价研究

ABSTRACT

Objective To discuss the efficacy of six ingredient rehmannia pill combined with metformin in treatment of type 2 diabetes with Qi-Yin deficiency.Methods 120 cases with type 2 diabetes were selected.They were divided into two groups randomly.The observation group (60 cases) took six ingredient rehmannia pill combined with metformin.The control group (60 cases) took metformin.The efficacy of interlocking intramedullary nail and fracture contusion capsule in treatment of open tibial fracutre was evaluated by fasting blood glucose,postprandial 2 h blood glucose,total symptom scores before and after treatment,adverse reaction during treatment.Results The effective rate of observation group was significantly higher than that of the control group (P ＜ 0.05).Before treatment,fasting blood glucose and postprandial 2 h blood glucose level had no significant difference between two groups.After treatment,the blood glucose of two groups were decreased (P ＜ 0.05).The fasting blood glucose and blood glucose 2 h after meal of observation group were lower than that of the control group (P ＜ 0.05).Before treatment,total symptom scores had no significant difference.After treatment,the two groups of the total symptom scores were decreased significantly (P ＜ 0.05),and the observation group the total symptom score lower than that of the control group (P ＜ 0.05).During the treatment,the control group of 1 cases of hypoglycemia,the observation group of 1 cases of hypoglycemia,1 cases of mild nausea.The adverse reactions of two groups had no significant difference.Conclusion Six ingredient rehmannia pill combined with metformin had good effect on type 2 diabetes.It could significantly improve the symptoms of diabetes diagnosed by traditional Chinese medicine.The hypoglycemic effect was obvious with high drugy safety.It was worthy of clinical application.