Serum levels of 25-(OH)D3 in patients with type 2 diabetes mellitus and its clinical significance / 国际检验医学杂志

ABSTRACT

Objective To examine the level of serum 25-hydroxyvitamin D3 [25-(OH)D3] and investigate the relationship be tween 25-(OH)D3 and islet B cell function as well as the insulin resistance in the newly diagnosed T2DM patients.Methods The general data and laboratory results of 48 newly diagnosed T2DM inpatients and 40 healthy subjects in the Nanjing Hospital of Chinese Medicine were collected.The laboratory parameters including fasting plasma glucose (FBG),serum insulin,serum lipids,HbA1c,25-(OH)D3,insulin homeostasis model assessment of insulin resistance(HOMA-IR) and function of β-cell(HOMA-β) were compared between the two groups.The linear analyses were conducted between serum 25-(OH)D3 level and HOMA-IR and HO MA-β.Results The level of FBG,serum lipid,HbA1c and HOMA-IR in T2DM group were significantly higher than those in the healthy subjects(P＜0.05),while the level of serum 25-(OH)D3 and HOMA-β were dramatically lower than the control group(P＜ 0.05).The 25-(OH)D3 level in the patients with T2DM was negatively correlated with FBG,HbA1c and HOMA-IR,(r=-0.30,-0.34,-0.23,P＜0.05),and positively correlated with HOMA-β(r=0.27,P＜0.05).Conclusion The insufficiency of 25-(OH) D3 is present in the newly diagnosed T2DM patients,which is correlated with insulin resistance and the decline of islet B cell function.These patients would benefit from supplementation of vitamin D.