Advances in Inflammatory Factors and Adipokines Involved in Rheumatoid Arthritis Complicated with Cardiovascular Disease / 医药导报

ABSTRACT

Rheumatoid arthritis ( RA ) is a chronic autoimmune disease characterized by erosive and symmetric synovitis.Chronic inflammation of RA increases the incidence of cardiovascular disease.Atherosclerosis caused by inflammation in blood vessels is the main complication of RA patients. Many inflammatory immune cells, inflammatory factors, and adipokines were involved in chronic inflammation in vascular. In patients with RA, high levels of inflammatory factors, such as C-reactive protein, tumor necrosis factor-α, interleukin 6, accelerated atherosclerosis and myocardial fibrosis. Some adipokines, including adiponectin,leptin and resistin, are also important factors causing cardiovascular diseases in patients with RA.In this paper, they review the research advances of inflammatory factors and adipokines involved in RA associated with cardiovascular disease.