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The influence of preoperative anxiety on popofol EC50 for no-movement during gastroscopy / 实用医学杂志
The Journal of Practical Medicine ; (24): 3434-3436, 2017.
Article in Chinese | WPRIM | ID: wpr-661401
ABSTRACT
Objective To investigate whether the median(50%)effective effect-concentration(EC50)of propofol inducing loss of consciousness (LOC) varies. Methods 56 patients undergoing gastroscopy under general anaesthesia were enrolled on the study. Anaesthesia was conducted with a target-controlled infusion(TCI) of propofol. The initial target effect-site propofol concentration (Ceprop) was 5.00 μg/mL and was adjusted stepwise by 0.50μg/mL by an up-down sequential method to reach no-movement. Results Propofol EC50 to induce no-movement was higher in patients with anxiety than those without anxiety(6.46μg/mL vs. 5.75μg/mL,P<0.05). Conclusions During general anaesthesia ,patients with anxiety had a higher propofol EC50 for no-movement compared with those without anxiety. Differences in preoperative anxiety levels may reduce anaesthetic effects.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: The Journal of Practical Medicine Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: The Journal of Practical Medicine Year: 2017 Type: Article