Research progress on tumor chemotherapy combined with photodynamic therapy and immunotherapy / 国际生物医学工程杂志

ABSTRACT

In recent years,the incidence of malignant tumors continually increased with the trend of younger age in onset age,which pose a serious threat to human health.At present,there are a variety of clinical anti-tumor treatments.However,a single treatment usually cannot achieve the best therapeutic effect.As a result,the combination therapy is often used in clinical practice.Combination therapy not only can enhance the therapeutic effect and reduce the toxic side effects of drugs,but also can alleviate the pain of patients.Chemotherapy is a commonly used clinical treatment for tumors.However,it can lead to greater side-effects,and cause irreversible damage to normal cells while killing the tumor cells.Photodynamic therapy uses the specific wavelengths of light to excite and activate the photosensitizer enriched in the tumor local.As a result,the tumor cells are killed directly or indirectly by photodynamic reactions with the participation of internal oxygen.Tumorassociated antigen will appear following the chemotherapy or photodynamic therapy.The immune system will stimulate the body to produce specific anti-tumor immune response after identifying the tumor-associated antigens.The combination treatment of chemotherapy and photodynamic therapy combined with immunotherapy not only can effectively improve the treatment effect of chemotherapy drugs and reduce drug side effects,inhibit tumor metastasis,but also can induce the production long-term anti-tumor immune response,so as to maximize the treatment effect.In this paper,the progress of the researches on chemotherapy,photodynamic therapy and immunotherapy in recent years were summarized.