Effect of Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin on arterial stiffness, blood viscosity and prognosis in patients with high-risk COPD / 重庆医学

ABSTRACT

Objective To investigate the effect of Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin on arterial stiffness,blood viscosity and prognosis in the patients with high-risk chronic obstructive pulmonary disease (COPD).Methods A total of 240 patients with high-risk COPD and risk factors of cardiovascular disease were divided into the statin group(A),Yiqi H uoxue H uatan group(B),combined group(C) and control group(D),60 cases in each group.All groups were treated with routine therapy.On this basis,the group A was combined with low-dose atorvastatin,the group B was combined with Yiqi Huoxue Huatan Formula.On the basis of the group A,the group C was combined with Yiqi Huoxue Huatan Formula.All groups were treated for 6 months.The changes of TCM syndrome scores,arterial stiffness index and blood rheological indexes in 4 groups were observed and compared between before and after treatment.The situation of adverse reactions occurrence and prognosis were recorded.Results After 6 months of treatment,the TCM syndrome scores and carotid artery-femoral artery pulse wave velocity (PWV)in 4 groups were significantly decreased compared with those before treatment,which in the group C,A,B and D was gradually increased (P＜ 0.05).After 6 months of treatment,there was no significant change of whole blood viscosity and hematocrit in the group D (P＞ 0.05),which in the other 3 groups were significantly decreased compared with those before treatment,moreover the group C was significantlylower than the group A and B (P＜0.05),while there was no statistically significant difference between the group A and B (P＞0.05).The incidence rate of adverse reactions had no statistically significant difference among the four groups (P＞ 0.05).The BODE index showed gradual increase ih the group C,A,B and D (P＜0.05).Conclusion Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin has an positive effect in regulating the blood rheological state and promoting the prognostic recovery in the patients with high-risk COPD and risk factors of cardiovascular disease.