Analysis of risk factors for extremely low birth weight infants with bronchopulmonary dysplasia / 重庆医学

ABSTRACT

Objective To explore the risk factors of extremely low birth weight infants(ELBWI) with bronchopulmonary dysplasia(BPD).Methods The clinical data in 151 ELBWI in NICU of the Provincial Hospital Affiliated to Shandong University and Sichuan Provincial People's Hospital from 2010 to 2015,admitted at 24 after birth and survived until to 28 h after birth,were performed the survey analysis.The newborns of oxygen dependency(FiO2 ＞ 21％) more than 28 d were included into the BPD group,on the contrary,the newborns were included into the non-BPD group.The maternal pregnant factors,neonatal factors and disease treatment factors were compared between the two groups.Results (1) Among 151 ELBWI,57 cases developed BPD with incidence rate of 37.7 ％.(2) The univariate analysis results showed that maternal chorioamnionitis,premature rupture of membrane more than 18 h,birth weight,gestational age,sepsis,patent ductus arteriosus (PDA),neonatal respiratory distress syndrome (NRDS),mechanical ventilation(MV),MV time,parenteral nutrition time,frequency of blood transfusion were associated with the BPD occurrence in ELBWI.Caffeine use was a protective factor.(3)The multivariate Logistic regression analysis displayed that MV (OR=6.975,95％CI1.464-33.219) and maternal chorioamnionitis(OR=3.890,95％CI1.656-9.140) were the independent factors of BPD occurrence in ELBWI.Conclusion Reducing intrauterine infection and preterm birth as far as possible and reasonable respiratory support after birth can effectively reduce the incidence rate of BPD in ELBWI.