Association between endothelial injury and organ dysfunction in sepsis / 中华实用儿科临床杂志

ABSTRACT

The definition of sepsis has been updated as life-threatening organ dysfunction caused by a dysregulated host response to infection according to the Third International Consensus Definitions for Sepsis and Septic Shock (SEPSIS-3).Sepsis affects functions of endothelial cell (EC) which include vasoregulation,barrier function,inflammation,hemostasis,and is thought to be the key factor in the progression from sepsis to organ failure.Recent studies also demonstrated the mechanism of endothelial dysfunction in sepsis is mediated by glycocalyx shedding.This review covers the current insight in sepsis-associated endothelial dysfunction in different organ systems,as well as the clinical assessmeut and clinical trial aiming at the system of endothelium.