Analysis on clinical efficacy of imipenem in treating 72 cases of stroke associated pneumonia / 重庆医学

ABSTRACT

Objective To evaluate the curative effect of imipenem on stroke associated pneumonia(SAP).Methods Seventy-two inpatients with SAP in ICU of the Affiliated Hospital of Southwest Medical University from January 2014 to January 2016 were selected.The patients were given the stroke associated treatment and symptomatic treatment.On this basis imipenem 1.0 g+ 0.9％ normal saline 100 mL was injected,once per 8 h.The disease condition change during treatment process was observed.The laboratory test results and chest CT changes were compared between before and after 2-week treatment.And the correlation analysis of risk factors was performed.Results Twelve cases died during treatment,60 cases were survival.The body temperature was declined to normal at 2 weeks after using imipenem.The NIHSS score,white blood cell (WBC) count,neutrophil count and C-reactive protein level after treatment were decreased compared with before treatment,the blood gas analysis showed that the arterial partial pressure of oxygen and oxygenation index were elevated compared with before treatment.The chest CT showed that pulmonary inflammatory exudation lesions and hydrothorax were absorbed and improved compared with before treatment.Among 72 cases,55 cases were cured,5 cases were remarkably effective,12 cases were ineffective,the total effective rate was 83.3 ％.The risk factors correlation analysis indicated that swallowing dysfunction,consciousness disturbance and acute attack history of chronic obstructive pulmonary disease were negatively correlated with the curative effect.Conclusion Imipenem has satisfactory effect in treating SAP.