Establishment of rat model of plateau hypoxia caused stress ulcer / 重庆医学

ABSTRACT

Objective To establish the rat experimental animal model of plateau hypoxia caused stress ulcer.Methods Rats were randomly divided into the normoxia group,plateau hypoxia 2,4,6,8,10 d groups.Except the normoxia group,the rats in other groups were fed in a hypobaric chamber(simulated altitude 5000 m) for 2,4,6,8,10 d srespectively.Then the gastric mucosal ulcer index,gastric juice volume,pepsin activity and PH value of gastric juice were observed in each group.Results Different degrees of point-like and line-like bleeding,erosion and ulcer formation could be seen in rat gastric mucosa in the hypobaric chamber(simulated altitude 5 000 m) on 2,4,6,8,10 d of plateau hypoxia;the ulcer index was significantly increased;the PH value and gastric juice volume were significantly decreased and the pepsin activity was significantly elevated.The changes of various indexes were most obvious on 6 d of plateau hypoxia.Conclusion Rats fed in a hypobaric chamber simulating a altitude of 5 000 m for 2-10 d can eastablish the altitude hypoxia caused stress ulcer animal model,moreover the optimal time is 6 d.