Molecular and Epidemiological Characterization of Carbapenem-Resistant Acinetobacter baumannii in Non-Tertiary Korean Hospitals
Yonsei Medical Journal
;
: 177-182, 2013.
Article
in English
| WPRIM
| ID: wpr-66224
ABSTRACT
PURPOSE:
The increasing prevalence and global spread of carbapenem-resistant Acinetobacter baumannii (A. baumannii) has become a serious problem. The aim of this study was to investigate molecular and epidemiological characteristics of carbapenem-resistant A. baumannii isolates collected from Korean non-tertiary hospitals. MATERIALS ANDMETHODS:
Thirty six non-duplicated carbapenem-resistant A. baumannii isolates were collected from 17 non-tertiary hospitals in Korea between 2004 and 2006. Isolates were typed by multilocus sequence typing and repetitive-sequence-based PCR (rep-PCR). Detection of genes encoding OXA carbapenemase and their relationship with ISAba1 was performed by PCR.RESULTS:
Two clones were prevalent among 36 isolates ST69 (17 isolates, 47.2%) and ST92 (19 isolates, 52.8%). Rep-PCR patterns were diverse and revealed that all isolates were clustered into eight band patterns. The ISAba1-activated blaOXA-23-like and ISAba1-activated blaOXA-51-like genes were prevalent among the carbapenem-resistant A. baumannii isolates.CONCLUSION:
The class D beta-lactamase genes of A. baumannii were distributed nationwide in non-tertiary Korean hospitals.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Beta-Lactamases
/
Acinetobacter Infections
/
DNA, Bacterial
/
Microbial Sensitivity Tests
/
Carbapenems
/
Polymerase Chain Reaction
/
Prevalence
/
Bacterial Typing Techniques
/
Molecular Epidemiology
/
Drug Resistance, Bacterial
Type of study:
Prevalence study
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Yonsei Medical Journal
Year:
2013
Type:
Article
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