Ipragliflozin in the treatment of type 2 diabetes:a Meta analysis / 重庆医学

ABSTRACT

Objective To evaluate the efficacy and safety of different doses of Ipragliflozin in the treatment of type 2 diabetes patients.Methods The randomized controlled trials (RCTs) about Ipragliflozin in treatment of type 2 diabetes patients were retrieved from the databases,including Cochrane Library,PubMed,Embase,Medline,CNKI,Wangfang,VIP and CBM.The data were extracted and evaluated by two researchers independently,and the Meta-analysis was performed via RevMan5.2.Results A total of 10 RCTs involving 1 928 patients were included.The results of Meta-analysis showed that glycosylated hemoglobin (HbA1c)[12.5 mg/dMD=-0.46,95％CI (-0.69,-0.23);25 mg/dMD=-0.97,95％CI (-1.00,-0.94);50 mg/dMD=-0.94,95％CI (-1.20,-0.69);100 mg/dMD=-0.93,95％CI (-1.72,-0.15);150 mg/dMD=-0.57,95％CI (-0.89,-0.26);200 mg/dMD=-0.74,95％CI (-1.14,-0.34);300 mg/dMD=-0.64,95％CI (-0.86,-0.43)],fasting blood glucose (FPG) [12.5 mg/dMD=-1.52,95％CI(-1.58,-1.47);25 mg/dMD=-1.98,95％CI (-2.04,-1.93);50 mg/dMD=-2.53,95％CI(-2.59,-2.48);100 mg/dMD=-3.27,95％CI(-3.32,-3.21);150 mg/dMD=-1.29,95％CI (-1.90,-0.68);200 mg/dMD=-3.34,95％CI (-4.78,-1.90);300 mg/dMD=-1.73,95％CI(-2.28,-1.18)] and body weight [12.5mg/dMD=-0.92,95％CI(-1.36,-0.47);25 mg/dMD=-1.30,95％CI (-1.81,-0.79);50 mg/dMD=-1.58,95％CI (-1.80,-1.35);100 mg/dMD=-1.31,95％CI(-1.65,-0.97);150 mg/dMD=-1.51,95％CI (-2.42,-0.60);300 mg/dMD=-1.73,95％ CI (-2.63,-0.83)] were significantly reduced in the different doses of Ipragliflozin group than that in the placebo group,and the dose of 50 mg/d and 100 mg/d were better.There was no significant difference in the incidence rate of the overall adverse reaction,hypoglycemic events,urinary tract infection and genital infection between the different doses of Ipragliflozin group and the placebo group (P＞0.05),but data showed that dose of 50 mg/d was more security than 100 mg/d (RR1.02 vs.2.18,1.83 vs.2.88,1.01 vs.1.72,1.85 vs.2.98).Conclusion Ipragliflozin is effective and safe for the patients with type 2 diabetes,which could effectively control the patients' HbA1c,FPG and body weight,and 50 mg/d may be the best dose.