Clinical efficacy of Yangyin Xiaoying decoction combined with western medicine in patients with Graves' disease / 重庆医学

ABSTRACT

Objective To investigate the clinical efficacy and its mechanism of Yangyin Xiaoying decoction combined with western medicine in the treatment of Graves' Disease.Methods A total of 50 patients suffered from Graves' Disease in our hospital were selected from January 2012 to December 2014,and were randomly divided into observation group and control group using random number table method,25 cases in each group.Other 25 cases of healthy subjects were selected in the same period in our hospital as the healthy control group.The control group received the treatment of methimazole,propranolol and other western medicine.The observation group received Yangyin Xiaoying decoction combined with western medicine.After 2 months of treatment,the levels of free triiodothyronine (FT3),free thyroxine (FT4),thyroid stimulating hormone (TSH),thyroglobulin antibody (TGAb) and thyroid peroxidase (TPOAb),and the percentages of Th1,Th2,Th17 cells in CD4+ cells and their corresponding cytokine levels were detected.Results After treatment,the levels of FT3,FT4,TGAb and TPOAb in the observation group and control group were significantly decreased,and levels of TSH were significantly increased in the two groups (P＜0.05);percentages of Th1,Th2 and Th17 cells in the observation group and control group were significantly lower than those before treatment (P＜0.05).After treatment,the interferon-γ (IFN-γ),interleukin (IL)-4 levels and IFN-γ/IL-4 ratio,IL-12,IL-5 levels and IL-12/IL-5 ratio in the observation group and control group were significantly lower than those before treatment (P＜0.05).The IL-17A,IL-17F and IL-23 levels in the observation group and control group after treatment were significantly decreased,compared with those before treatment (P＜0.05).The degree of improvement of above indexes in the observation group were better than those in the control group (P＜0.05).Conclusion Yangyin Xiaoying decoction combined with western medicine can significantly improve patients' thyroid function,which suggests that it may have a role in the therapy in the treatment of Graves' disease.