Changes of serum cortisol and IL-6 levels before and after exercise stress test and their relationship with white coat hypertension / 国际检验医学杂志

ABSTRACT

Objective To investigate the changes of serum cortisol and IL-6 levels before and after exercise stress test and their relationship with white coat hypertension .Methods A total of 48 patients with white coat hypertension in Liwan Hospital of Tra-ditional Chinese Medicine from January 2014 to August 2016 were selected as the study group ,30 cases of patients with common hypertension in the same period were selected as common group ,30 cases of healthy volunteers in the same period were selected as control group .All the objects in the three groups completed exercise stress test on an empty stomach ,sat on the power bicycle and pedaling 2 min with 200 W ,and after intermittent 5 min repeated exercise until extreme fatigue .Serum cortisol and IL-6 levels ,mean arterial pressure(MAP) of 3 groups before exercise ,immediately after exercise and 3 h after exercise were detected and compared . Value of serum cortisol and IL-6 on diagnosing white coat hypertension and its relationship with MAP were analyzed .Results Compared with the control group ,serum cortisol ,IL-6 levels and MAP of the study group and common group before and after exer-cise were increased .Compared with the common group ,serum cortisol and IL-6 levels and MAP of the study group were significant-ly increased immediately after exercise and 3 h after exercise (P<0 .05) .Compared with before exercise ,serum cortisol and IL-6 levels and MAP of the study group immediately after exercise and 3 h after exercise were increased(P<0 .05) .ROC curve analysis showed that it′s value to detecting serum cortisol and IL-6 levels before and after exercise stress test for diagnosing white coat hy-pertension ,in which the value of combined detection of serum cortisol and IL-6 immediately after exercise for diagnosing white coat hypertension was the best .Pearson linear correlation analysis showed that serum cortisol and IL-6 levels before and after exercise stress test were positively correlated with MAP of patients with white coat hypertension (r=0 .844 ,0 .802 ,P<0 .05) .Conclusion It′s value to detecting serum cortisol and IL-6 levels before and after exercise stress test for diagnosing white coat hypertension , which are related with blood pressure ,and could be used as reference indexes for the diagnosis and illness severity evaluation of white coat hypertension .