An analysis of the changes of serum lipid and liver enzyme content in patients with primary hypothyroidism before and after treatment / 中华地方病学杂志

ABSTRACT

Objective To observe the changes of serum lipid and liver enzyme after levothyroxine sodium treatment in patients with primary hypothyroidism.Methods Data from 104 patients with primary hypothyroidism together with increased serum lipid and liver enzyme were collected from August 2006 to November 2015.The date were compared of the changes of thyroid three triiodothyronine (T3),thyroxine (T4),free three triiodothyronine (FT3),free thyroxine thyroid (FT4),thyroid stimulating hormone (TSH),total cholesterol (TC),glycerol triester (TG),high density lipoprotein (HDL-C),low density lipoprotein (LDL-C),alanine aminotransferase (ALT),aspartate aminotransferase (AST) before the levothyroxine sodium treatment and after three month of the treatment.Results After three months of levothyroxine sodium treatment,thyroid function (T3,T4,FT3,FT4,TSH) gradually returned to normal levels [(2.02 ± 0.40) vs (0.96 ± 0.24) nmol/L,(95.76 ± 15.23) vs (24.31 ± 9.99) nmol/L,(4.79 ± 0.58) vs (1.96 ±0.57) pmol/L (15.15 ± 1.77) vs (4.70 ± 1.57) pmol/L,(3.05 ± 1.00) vs (82.41 ± 17.18) mU/L,t =-23.57,-44.13,-34.03,-46.48,48.07,P ＜ 0.01],TC,TG,LDL-C,ALT,AST apparently decreased [(4.30 ± 0.67) vs (7.54 ± 1.26) mmol/L,(2.05 ± 0.34) vs (2.14 ± 0.47) mmol/L,(2.35 ± 0.49) vs (4.28 ± 0.88) mmol/L,(23.31 ±3.92) vs (46.27 ± 0.98)U/L,(26.63 ± 4.64) vs (55.33 ± 11.99) U/L,t =33.68,4.24,24.87,29.36,33.83,P ＜0.01],the decrease was less obvious than before treatment in HDL-C [(1.62 ± 0.36) vs (1.63-± 0.38) mmol/L,t =1.49,P ＞ 0.05].Conclusion Levothyroxine sodium treatment in patients with hypothyroidism can effectively reduce blood lipid and liver enzyme content.