Curative effect of Shuxuening injection for patients with acute pancreatitis and which influence on the oxidative stress / 药物评价研究

ABSTRACT

Objective To explore the curative effect of Shuxuening injection for patients with acute pancreatitis and which influence on the oxidative stress.Methods 150 patients with acute pancreatitis were enrolled in our hospital from December 2013 to November 2016,of which patients divided into two groups randomly,control group (n =65) accepted conventional therapy,and study group (n =85) adopted Shuxuening injection based on the treatment of control group.The curative effect of two groups were evaluated,and the factors of inflammatory and oxidative stress response were detected responsibly before and after treatment,the pancreatic injury degree were evaluated via the gauge of APACHE Ⅱ and BISAP.Results The total effective rate of study group for curative effect was higher significantly than those patients in control group (P ＜ 0.05);After treatment,the tumor necrosis factor α (TNF-α),interleukin-6 (IL-6) and malondialdehyde (MDA) of two groups decreased significantly compared with before treatment (P ＜ 0.05),and the level of which factors in study group were lower than those control group,and which difference was significance (P ＜ 0.05),the superoxide dismutase (SOD) of all patients increased significantly compared with before treatment (P ＜ 0.05),and SOD level of patients in study group was higher than those patients in control group (P ＜ 0.05);the APACHE Ⅱ[and BISAP score of all patients went down remarkably compared with before treatment (P ＜ 0.05),and which score of patients in study group was lower than that control group,and which difference was significance (P ＜ 0.05).Conclusions Shuxuening Injection for patients with acute pancreatitis deserved popularization in clinic,which not only decreased the inflammatory and oxidative stress response significantly,but also increased the curative effect remarkably.