Kyphoplasty with polymethylmethacrylate bone cement treats Kummell disease in the elderly / 中国组织工程研究

ABSTRACT

BACKGROUND: Percutaneous kyphoplasty is an effective method for the treatment of osteoporotic vertebral compression fracture, because it can relieve pain quickly, restore the vertebral height and correct kyphosis. However, little is reported on percutaneous kyphoplasty for the treatment of Kummell disease. OBJECTIVE: To evaluate the efficacy and safety of kyphoplasty with polymethylmethacrylate bone cement in treating Kummell disease in the elderly. METHODS: Thirty-one patients (6 males and 25 females) with Kummell disease, aged 58-72 years old, were included in this study. Affected segments involved T11 in 5 cases, T12 in 11 cases, L1 in 8 cases, L2 in 4 cases, L3 in 2 cases, L4 in 1 case. All the patients underwent percutaneous kyphoplasty with polymethylmethacrylate bone cement. The clinical effect was evaluated by pain, viability and imaging changes before and after therapy. RESULTS AND CONCLUSION: (1) Pain relief The visual analogue scale score for all the 31 patients at 3 days, 3 months and 12 months after the surgery were significantly lowered compared to the preoperative scores (P < 0.05). (2) Viability The mean Oswestry disability index scores for 31 patients at 3 days, 3 months and 12 months after the surgery were significantly lowered compared to the preoperative scores (P < 0.05). (3) Imaging evaluation The anterior vertebral height and vertebral height at middle line for 31 patients at 3 days, 3 months and 12 months after the surgery were higher compared to the preoperative data (P < 0.05), and Cobb angles were significantly lowered compared to the preoperative data (P < 0.05). (4) Adverse reaction There was no leakage of bone cement in the vertebral canal and vein, and no adverse reaction occurred related to bone cement. In summary, the kyphoplasty with polymethylmethacrylate bone cement is safe and effective in treating Kummell disease in the elderly. It can fast relieve pain, improve patients quality of life, and reconstruct the spinal stability.