Advances on studies of miR-21 in vascular endothelial function and angiogenesis / 中国病理生理杂志

ABSTRACT

MicroRNAs ( miRNAs) are a class of non-coding , endogenous , single-stranded small RNA mole-cules composed of 19~25 nucleotides .miRNAs are widely involved in the process of human life activities .Recent studies have shown that part of miRNAs regulate the vascular endothelial function and angiogenesis .High expression of miRNA-21 is found to play important roles in the cell proliferation , cell apoptosis , cell growth and death of vascular endothelial cells . This review will focus on the recent progress related to miRNAs in vascular endothelial function and angiogenesis , providing a new insight in cardiovascular disease prevention , clinical diagnosis , prognosis and target therapeutics .