Relevance between the occurrence of chronic obstructive pulmonary disease and mitochondria DNA haplogroups / 基础医学与临床
Basic & Clinical Medicine
;
(12): 1729-1732, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-663206
ABSTRACT
Objective To identify the relation between peripheral leukocytes mitochondria DNA(mtDNA) haplo-group and chromic obstructive pulmonary disease(COPD).Methods Sixty COPD patients and 45 healthy con-trols were recruited from Taihe Hospital .mtDNA hypervariable ( HVS ) region and 10171-10659 region were cloned and sequenced.Mutation sites were analyzed via aligning the target gene sequence with the rCRS ( revised Cambridge Reference Sequence) of mtDNA.Samples were divided into possible haplogroup according to mtDNA haplogroup classification tree of Han population.Results Both COPD group and control group were divided into 9 kinds of haplogroup, such as A, F and M7.A haplogroup has a higher proportion in COPD group than control group ( P<0.05) , while F haplogroup has a higher proportion in the control group than COPD group ( P<0.05) . Conclusions F haplogroup may reduce the COPD risk, while A haplogroup may be risk factor for COPD.The occurrence and development of COPD is potentially related to mtDNA haplogroup mutation .
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Basic & Clinical Medicine
Year:
2017
Type:
Article
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