Increased serum surfactant protein-D in the infants with acute respiratory syncytial virus bronchiolitis
Allergy, Asthma & Respiratory Disease
;
: 235-240, 2013.
Article
in Korean
| WPRIM
| ID: wpr-66332
ABSTRACT
PURPOSE:
Collectin family is an important component of innate immunity, of which surfactant protein (SP)-D and mannose-binding lectin (MBL) are the most characterized. We examined SP-D and MBL in young children with acute respiratory syncytial virus (RSV) bronchiolitis.METHODS:
Sixty-three children (7 days of hospital stay. All children were evaluated if they had recurrent wheezing during follow-up. SP-D and MBL were measured using enzyme-linked immunosorbent assay in serum collected on admission and compared with controls. Their levels were evaluated in relation to the symptom severity during admission and recurrence of wheezing after discharge.RESULTS:
Serum SP-D increased significantly in the patients (P<0.01), but MBL showed no difference compared to the controls. SP-D levels were significantly higher in severe group compared with nonsevere group (P<0.05). SP-D levels in the patients with recurrent wheezing after discharge were significantly higher than in those without (P<0.05). MBL showed no difference in relation to the symptom severity or recurrence of wheezing.CONCLUSION:
Our study showed that serum SP-D was associated with the severity of RSV bronchiolitis and suggests that it might be a biomarker of lung injury and recurrence of wheezing illnesses in the young children admitted with their first RSV bronchiolitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oxygen
/
Recurrence
/
Respiration
/
Respiratory Syncytial Viruses
/
Enzyme-Linked Immunosorbent Assay
/
Bronchiolitis
/
Respiratory Sounds
/
Follow-Up Studies
/
Thoracic Wall
/
Collectins
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Child
/
Humans
/
Infant
Language:
Korean
Journal:
Allergy, Asthma & Respiratory Disease
Year:
2013
Type:
Article
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