Analysis on correlation between CYP17 gene polymorphism and hyperandrogenmia in Xinjiang Uyghur patients with polycystic ovary syndrome / 国际检验医学杂志

ABSTRACT

Objective To investigate the correlation between the CYP17 gene polymorphisms and hyperandrogenemia(HA) in Uygur women patients with polycystic ovary syndrome (PCOS ) .Methods 59 Uygur patients with PCOS were selected as the Uygur PCOS group and re-divided into the Uygur PCOS complicating HA group and Uygur PCOS non-complicating HA group . Meanwhile 18 Han patients with PCOS complicating HA were selected as the Han PCOS group .The polymerasechain reaction-restrictive fragment length polymorphism method was used to examine the basic group polymorphisms in the promoter region of CYP17 gene .Then the correlation between basic group locus polymorphism and Uygur PCOS complicating HA was analyzed .Results There was no statistically significant difference between TT ,TC and CC genotypes and T ,C allele frequencies in the Uygur PCOS non-complicating HA group and Uygur PCOS complicating HA group (P＞ 0 .05) .There was no statistically significant difference between TT ,TC and CC genotypes and T ,C allele frequencies in the Uygur PCOS complicating HA group and Han P-COS group(P＞0 .05) .The serum testosterone level in TT ,TC and CC genotypes patients of the Uygur PCOS complicating HA group was significantly higher than that in the Uygur PCOS non-complicating HA group(P＜0 .05) .Serum testosterone level had no statistically significant difference between TC ,CC genotypes and TT genotype patients of Uygur PCOS group(P＞0 .05) .Conclusion The distribution frequency of CYP17 genotypes does not increase the risk suffering from HA in Uygur women .Single nucleotide polymorphism in CYP17 gene promoter region had no obvious correlation with Uygur PCOS complicating HA occurrence .