Clinical Significance of Detecting Serum IL-6,IFN-γ,TNF-α and TPO-Ab in Pregnant Women of Patients with Postpartum Thyroiditis / 现代检验医学杂志

ABSTRACT

Objective To investigate the serum of patients with postpartum thyroiditis(Postpartum thyroiditis,PPT)in the serum of patients with interleukin 6(IL-6)and interferon gamma(IFN-γ)tumor necrosis factor(TNF-α)and anti thyroid peroxidase antibody(TPO-Ab)the clinical significance of detecting content.Methods 34 cases of postpartum thyroiditis were selected in the First Affiliated Hospital of Xi'an Medical University from September 2013 to August 2015.They were treated as the observation group,and selected 34 subjects for health check in the First Affiliated Hospital of Xi'an Medical College at the time as control group.Early in the morning,they all were taken 2 tube of verous blood on an emptystomach and separated serum.Serum IL-6,INF-γ,TNF-α and TPO-Ab of the goups were detected with RATA and antibody sand-wich ELISA,and the differences were compared between the two groups.Results Compared to healthy subjects of 3 kinds of cytokines and antibody levels in the blood of patients with PPT,the data were significantly higher and the difference was statistically significant(t=-98.154,-63.627,-94.090,P<0.05).The content correlated positively with the content of TPO-Ab between the 3 kinds of cytokines in blood of PPT patients(RIL-6=0.852,RTNF-α=0.658.RIFN-γ=0.836).Conclusion Postpartum inflammatory factors and immune factors in the blood of patients with thyroiditis in secretion increased signifi-cantly,the content of TPO-Ab and the 3 factor was positively related to the pathogenesis of PPT,concluded that the 3 kinds of inflammatory factors are involved,so it can be used as basis for diagnosis of patients with PPT,and can provide reference for effective treatment.