Clinical Value of Presepsin in the Diagnosis and Prognosis of Bacterial Infection in Cirrhosis / 现代检验医学杂志

ABSTRACT

Objective To observe and evaluate the clinical value of presepsin level in cirrhosis-associated bacterial infections. Methods 30 cirrhosis patients with bacterial infections were enrolled as study group.At admission,60 cirrhosis patients without bacterial infections were enrolled as control group.The difference of blood presepsin level between two groups were analyszed and compared the relationship between level of presepsin patients.The level of presepsin of survival and death group were compared and analyszed risk factors for the prognosis of bacterial infection by COX multi-factor analysis.The sensitivity and specificity were compared by PCT,CRP and presepsin detection.Results The blood presepsin level of study group was 1 002.3(575.1 2~149.5)pg/ml,the blood presepsin level of control group was 475.0(332.7~680.2)pg/ml. The presepsin of study group was significantly higher than control group,the difference was statistically significant(t=1.865,P<0.05).The presepsin level of death patients was significantly higher than survival patients(t=5.875,P<0.05). COX multi-factor analysis showed that presepsin levels were independent risk factors affecting the prognosis of bacterial in-fection in patients with liver cirrhosis.There were statistically significant of sensitivity and specific degrees between presep-sin and CRP(P<0.05).Conclusion Presepsin level is a valuable new biomarker for defining severe infections in cirrhosis. The increase of Presepsin level can be used as a judgment is an important index indicator of liver cirrhosis bacterial infection. It was worthy of clinical attention.