Risk factors of hypertension complicated with coronary heart disease / 实用医学杂志

ABSTRACT

Objective To investigate the risk factors of hypertension patients combined with coronary artery disease(CAD)and analyze the correlation. Methods A total of 258 hospitalized hypertension patients from August 2015 to December 2016 were divided into hypertension group(n = 124)and hypertension combined with CAD group(n = 134),according to the results of coronary angiography. The general data,platelet parame-ters,blood lipid level and renal function indexes of all objects were recorded. The differences of all indexes between 2 groups were compared,and the correlation between these indexes and CAD in hypertensive patients was analyzed. Results(1)More smokers and older patients were found in hypertension combined with CAD group;the values of mean platelet volume(MPV),platelet distribution width,creatinine,serum uric acid were higher, but HDL-C level was lower and all the differences were statistically significant(P < 0.05).(2)Multivariable logistic regression analysis demonstrated that age,smoking history,MPV,serum uric acid and low level of HDL-C were independent hazardous factors of CAD in hypertensive patients[OR = 1.062,95% CI1.032 ~ 1.093;OR =2.048,95% CI1.078~3.893;OR=2.737,95% CI1.193~6.278;OR=1.006,95% CI1.001~1.010;OR=0.280,95% CI0.115~0.681(all,P<0.05)].(3)Pearson correlation analysis showed that MPV was positively correlated with serum uric acid(r = 0.17,P < 0.05). Conclusions Age,smoking history,MPV,serum uric acid and lower HDL-C value are risk factors of CAD in hypertensive patients and active detection and prevention will benefit reducing the risk for the occurrence of CAD in hypertensive patients.