Dietary therapy in children with autism spectrum disorder / 国际儿科学杂志

ABSTRACT

Autism spectrum disorder(ASD)is a severe neurodevelopmental disorder of children that leads to disability which lacks of effective treatment.The specific pathogenesis of ASD remains unclear,which may involve in multiple factors.In recent years,many studies have shown that children with ASD have gastroin-testinal(GI)abnormalities and some special diet therapies can effectively ameliorate the symptoms of ASD. These diets include gluten free diet,sensitive or harmful food removing therapy and ketogenic diet.The patients with ASD have GI inflammation or allergy,energy metabolism disorder,oxidative stress injury,neurotransmitter disturbance and dysbiosis of intestinal flora.Diet therapy may improve ASD symptoms by correcting disorders a-bove.This article reviews the application and the related mechanism of diet therapy in ASD children and the effect of diet therapy on the growth and the development of children.