Advances in research on the role of Siglec-1 in diseases / 中国比较医学杂志
Chinese Journal of Comparative Medicine
;
(6): 109-114, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-663882
ABSTRACT
Sialoadhesin ( Siglec-1 or CD169 ) is a sialic acid-binding Ig-like lectin expressed selectively on macrophage subsets. In inflammatory response, Siglec-1 can modulate the secretion of MIP-1 alpha / beta, MCP-1, MIP-2 and other cytokines, and promote the occurrence of inflammatory reaction. During viral infection, Siglec-1 can promote the infection and phagocytosis of virus by mediating the binding of pathogens and macrophages. In the regulation of immunity, Siglec-1 can regulate innate immunity and adaptive immunity, by inhibiting the excessive expression of IFN-α and the activation of DC cells. This review mainly focuses on the new advances of research on Siglec-1 in pathogen infections, inflammation and immunoregulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Comparative Medicine
Year:
2017
Type:
Article
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