Expression of human epidermal growth factor receptor 2 in breast cancer tissues and its relationship with prognosis / 中国综合临床

ABSTRACT

Objective To investigate the expression of human epidermal growth factor receptor 2 (HER2)and its relationship with prognosis in breast cancer patients.Methods One hundred and ninety-eight patients with breast cancer treated with breast surgery in Jizhong Energy Fengfeng Group Hospital from January 2007 to October 2011 were selected as the research objects.The expression of HER2 in 198 cases of breast cancer and 108 cases of breast adenoma at the same time were compared.The 5 year disease-free survival and overall survival rate of breast cancer patients with HER2 positive and negative expression were analyzed and compared.Cox regression analysis was used to analyze the prognosis.Results The positive expression of HER2 in breast cancer tissues was showed in 93 cases,the negative expression was observed in 105 cases,the positive rate was 47.0%(93/198); the positive rate in the breast adenoma group was 0(0/108).The difference between the two groups in the positive rate was statistically significant(P=0.000).The 5 year disease-free survival rate and overall survival rate of the breast cancer patients in the HER2 positive group was 80.8% and 82.9%,respectively.The 5 year disease-free survival rate and overall survival rate was 94.6% and 97.2% in the HER2 negative group,respectively.The differences between the two groups was statistically significant(P=0.046,0.045).The tumor diameter,clinical stage,lymph node metastasis and HER2 positive expression were the independent risk factors for disease-free survival rate and overall survival rate of breast cancer patients(RR=1.59,1.51,5.45,1.72,95%CI=1.00 ~ 2.50,1.10 ~ 17.03,2.00 ~ 5.39,1.10~1.68,P<0.05).The tumor diameter,clinical stage,lymph node metastasis and HER2 positive expression were the independent risk factors for overall survival rate of breast cancer patients(RR=1.70,1.630,4.29,2.08,95%CI=1.02~2.80, 1.12~15.87,2.40~7.59,1.28~3.42,P<0.05).Conclusion Overexpression of HER2 in breast cancer can promote the occurrence,development and metastasis of breast cancer and that is an independent risk factor to predict the prognosis of breast cancer patients.