(Pro)renin receptor in heart disease / 国际儿科学杂志

ABSTRACT

The renin-angiotensin system is an important body fluid regulation system in the human body,and it normally plays a significant role in the normal development and homeostatic regulation of the cardio-vascular system,the maintenance of electrolyte and body fluid balance,and the regulation of blood pressure.The (pro)renin receptor[(P)RR ] was been discovered as an important novel component of the renin-angiotensin system.It binds both prorenin and renin in tissues.(P)RR is widely expressed in human body,including kidney, brain,heart and placenta.It has been proved that the activated(P)RR participates in the activation of multiple in-tracellular signaling pathways and plays an important role in the pathogenesis of diabetic complications,hyperten-sion,heart failure and myocardial fibrosis.This review mainly summarizes the research progress of expression and function of(pro)renin receptor in the heart.