Study on the changes of insulin ,C peptide and blood glucose levels in diabetic with liver damage patients and its clinical significance / 国际检验医学杂志

ABSTRACT

Objective To explore the early diagnosis value of insulin ,C peptide ,blood glucose detection in diabetic patients with liver damage .Methods A total of 120 cases of diabetic patients were selected from January 2014 to January 2016 ,all of them were divided into 53 cases of diabetes mellitus complicated with liver injury group (Study Group 1) and 67 cases of diabetes with normal liver function group (Study Group 2) ,and 50 cases healthy people in the same period were selected as the control group .fasting blood glucose (FBG) ,2 Hours Postprandial Blood Glucose (2hPG) ,Glycosylated Hemoglobin (HbA1c) ,fasting insulin (FINS ) ,2 h postprandial fasting insulin (P2INS) ,homeostasis model assessment-insulin resistance index (HOMA-IR) ,c-peptide (CP) and (2 hour postprandial fasting C peptide) P2CP levels of every group were detected ,and the correlation with indexes and liver damage was analyzed .Results FBG ,2hPG ,HbA1c ,FINS ,P2INS ,HOMA-IR ,CP ,P2CP levels in Study group 1 and Study Group 2 were significantly higher than those in the control group (P<0 .05) ,and each index level in Study group 1 was significantly higher than that in study Group 2(P<0 .05);correlation analysis showed that the diabetes mellitus combined with liver damage was positively correlated with FBG ,2hPG ,HbA1c ,FINS ,P2INS ,CP ,P2CP levels (r=0 .274 ,0 .190 ,0 .220 ,0 .230 ,0 .195 ,0 .083 ,0 .289 ,0 .724 re-spectively ,P<0 .05) .Conclusion Pancreatic islet function and blood glucose metabolism play an important role in diabetic patients with liver damage ,and three indexes combined detection can be used as early diagnosis of diabetes mellitus combined with liver damage .