Content Determination and Dissolution Detection of Magnesium Valproate Tablets by GC Internal Standard Method / 中国药师
China Pharmacist
;
(12): 2260-2263, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-664088
ABSTRACT
Objective:
To establish a GC determination method for the content and dissolution of magnesium valproate tablets.Methods:
Magnesium valproate tablets were detected by a GC internal standard method. The samples were dissolved in 0. 1 mol·L-1 hydrochloric acid solution, and then extracted by dichloromethane. Eicosane was used as the internal standard. The dissolution was de-termined by the first method described in ChP 2015 edition. The dissolution medium was 0. 1 mol·L-1 hydrochloric acid solution and the rotation speed was 100 r·min-1 with the sampling time at 45 min. The samples were extracted by dichiormethane, and eicosane was used as the internal standard as well.Results:
The dissolution of magnesium valproate tablets showed good linearity within the range of 0. 005-1. 000 mg·ml-1(r=0. 9999). The recovery was 99. 2% (RSD=0. 5%, n=9). The dissolution curve showed that magnesium valproate released above 80% in 45 minutes.Conclusion:
The method has good specificity and high accuracy, and can be used for the content determination and dissolution detection of magnesium valproate tablets.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
China Pharmacist
Year:
2017
Type:
Article
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