Study on effect of self-made Guben Pingchuan Huatan decoction on curative effect and laboratory indexes of patients with chronic obstructive pulmonary disease / 国际检验医学杂志

ABSTRACT

Objective To investigate the effect of self-made Guben Pingchuan Huatan decoction on curative effect and laboratory indexes of patients with chronic obstructive pulmonary disease .Methods 98 patients with chronic obstructive pulmonary disease (COPD) in stable stage in our hospital from September 2014 to September 2016 were selected and divided into observation group with 49 cases and control group with 49 cases according to the random number table method .The control group was given tiotropi-um bromide treatment ,while the observation group were given the basic treatment the same as the control group with the combina-tion of self-made Guben Pingchuan Huatan decoction .Two groups were treated for a period of 3 months .The therapeutic effects of the two groups were compared ,and the changes of pulmonary function ,6MWT and serum inflammatory factors before and after treatment were compared .Results The total effective rate in the observation group was higher than that in the control group (P<0 .05);FEV1 expected value ,PEF and FEV1/FVC value of the two groups after treatment were increased (P<0 .05);FEV1 expec-ted value ,PEF and FEV1/FVC value of the observation group were higher than those of the control group after treatment ,and the difference was statistically significant (P<0 .05);6MWT of two groups after treatment was increased (P<0 .05);6MWT of the observation group after treatment was higher than that of the control group ,and the difference was statistically significant (P<0 .05);IL-6 ,IL-8 and MMP-9 levels were decreased after treatment in two groups (P<0 .05);IL-6 ,IL-8 and MMP-9 levels of the observation group were lower than those of the control group ,and the difference was statistically significant (P<0 .05) .Conclusion The self-made Guben Pingchuan Huatan decoction has a remarkable curative effect on chronic obstructive pulmonary disease ,and can significantly improve the pulmonary function of patients ,and lower serum inflammatory cytokines IL-6 ,IL-8 and MMP-9 levels , thereby reducing the inflammatory state of patients .