Perinatal complications and neonatal outcomes of twin pregnancies conceived by assisted reproductive techniques and those conceived spontaneously: A retrospective analysis of 811 cases / 解放军医学杂志

ABSTRACT

Objective To investigate the general situations of gravida,pregnancy complications,childbirth and neonatal outcomes of twin pregnancies conceived by assisted reproductive techniques (ART) and those conceived spontaneously.Methods A retrospective analysis was carried out on the basic information,perinatal complications,delivery information and neonatal outcomes of twin pregnancies received by ART (ART group,n=518) and those conceived spontaneously (SC group,n=293).Results Gravida age was older in ART group than in SC group (P＜0.05),while the gravidity and parity in ART group was more than that in SC group (P＜0.05).There were more embryos and high proportion of diamniotic cyst in ART group than in SC group (P＜0.05).The gestational incidence of diabetes,abnormal placenta (placental adherence,placenta accrete,placenta previa) and postpartum hemorrhage were higher in ART group than in SC group (P＜0.05),while no statistically significant differences existed between the two groups in the incidence of gestational complications (such as gestational hypertension disease,cholestasis and amniotic fluid volume abnormality) and in neonatal outcomes including neonatal weight,incidence of asphyxia and congenital malformation and neonatal death (P＞0.05).Conclusion Twin pregnancy conceived by ART may lead to higher incidences of gestational diabetes mellitus and abnormal placenta and more postpartum hemorrhage,but no significant difference existed in the neonatal outcomes between twin pregnancies conceived by ART and those conceived spontaneously.