Selection of an Antidepressant Based on the Genotypes of Cytochrome P450 Enzymes Genes in a Patient with Major Depressive Disorder / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 324-328, 2005.
Article
in Korean
| WPRIM
| ID: wpr-66430
ABSTRACT
We present a case of 34-year-old female patient with major depressive disorder who had decreased metabolic activity of CYP2D6. Low dosage regimen of mirtazapine & paroxetine led to unexpectedly severe adverse effects and noncompliance in this case with genotype CYP2D6 *1/*5. Antidepressant change to imipramine with consideration of the genotyping resulted with tolerable adverse effects and remission of depression. This case suggests the clinical usefulness of pharmacogenetic testing in individualized antidepressant treatments.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacogenetics
/
Paroxetine
/
Cytochrome P-450 CYP2D6
/
Cytochrome P-450 Enzyme System
/
Cytochromes
/
Depression
/
Depressive Disorder, Major
/
Genotype
/
Imipramine
Limits:
Adult
/
Female
/
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2005
Type:
Article
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