Research progress of FBXW7 in ovarian cancer / 中国综合临床
Clinical Medicine of China
;
(12): 1142-1145, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-664300
ABSTRACT
As a tumor suppressor gene,FBXW7 is a member of the F-box protein family,and FBXW7 can regulates cell growth and cycle progression.FBXW7 has more than 20 substrates,most of which are cancer proteins,and a few are tumor suppressor factors,which are highly expressed in most tumors.FBXW7's gene deficiency or deletion can cause chromosome instability and lead to tumorigenesis.In this paper,the molecular structure,functional characteristics and the mechanism of action in gynecological malignant tumors of ovarian cancer are reviewed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Clinical Medicine of China
Year:
2017
Type:
Article
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