Add-On Therapy of Quetiapine for Bipolar Disorder: A 6 Month, Prospective Trial / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 279-284, 2005.
Article
in Korean
| WPRIM
| ID: wpr-66436
ABSTRACT
OBJECTIVES:
This study was conducted to evaluate the overall effectiveness and tolerability of adjunctive quetiapine in the long-term treatment of bipolar disorder as a continuation therapy.METHODS:
Twenty-three bipolar I patients participated and required to have quetiapine add-on treatment in combination with existing or new mood stabilizers. Clinical assessment was carried out using Young Mania Rating Scale (YMRS), Clinical Global Impression (CGI), Hamilton Depression Rating Scale-17 item, Simpson-Angus Rating Scale and Barnes Akathisia Rating Scale at baseline, 1, 4, 12 and 24 weeks.RESULTS:
The YMRS and CGI decreased significantly from baseline to endpoint by 89.7% and 78.3%, respectively (p<0.0001 ; p<0.0001). Twenty-two patients exhibited at least 50% improvement on YMRS score by the end of the study.CONCLUSION:
This study suggests that quetiapine may hold a promise as an adjunct in the long-term treatment of bipolar disorder.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychomotor Agitation
/
Bipolar Disorder
/
Prospective Studies
/
Depression
/
Quetiapine Fumarate
Type of study:
Observational study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Psychopharmacology
Year:
2005
Type:
Article
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