Association of 25-hydroxyvitamin D with dry eye / 眼科新进展

ABSTRACT

Objectire To investigate the correlation of 25-hydroxyvitamin D [25 (OH) D] with the occurrence of dry eye (DE).Methods Fifty-eight patients with DE (DE group) and 30 healthy controls (control group) were enrolled in the study.Serum 25-hydroxyvitamin D level was detected by ELISA.The correlation between serum 25-hydroxyvitamin D and ocular surface disease index (OSDI) scales,tear film break-up time (BUT) and Schirmer I test (SIT) was analyzed.Results The SIT of DE group was significantly lower than that of the control group [(7.47 ± 3.01)mm · 5 min-1 vs.(14.56 ± 3.48) mm· 5 rmin-1] (t =9.926,P =0.000),and the BUT of DE group was significantly lower than that of the control group [(6.03 ± 2.14) t · s-1 vs.(12.05 ± 3.27)t · s-1] (t =10.392,P =0.000),while OSDI score of the DE group was significantly higher than that of the control group [(36.19 ± 17.23) vs.(16.67 ± 5.01)] (t =6.059,P =0.000).Moreover,serum 25 (OH)D level of the DE group was significantly lower than that hn the healthy controls [(18.42 ±7.57)ng · mL-1 vs.(32.49 ± 12.85) ng · mL-1) (t =6.467,P =0.000).Serum 25 (OH) D deficiency was more common in the DE group (x2 =30.995,P =0.000).Pearson correlation analysis showed that serum 25 (OH) D level was positively correlated with SIT (r =0.652,P =0.000),but negatively correlated with BUT (r =-0.531,P =0.000) and OSDI (r =-0.480,P =0.000).Conclusion Low serum 25 (OH) D level may be associated with the initiation of DE.