Literature Analysis of Sunitinib-induced ADR / 中国药房
China Pharmacy
;
(12): 4932-4935, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-664393
ABSTRACT
OBJECTIVE:
To provide reference for safe use of sunitinib in clinic.METHODS:
Using"sunitinib""ADR"as re-trieval words,retrieved from PubMed,VIP,CNKI and Wanfang database during Jan. 2006-Mar. 2017,case reports and case series reports about sunitinib-induced ADR were collected and screened. In retrospective study,general information of patients,disease in-formation,involved organs or systems,clinical manifestations,ADR association evaluation and outcomes were analyzed statistical-ly.RESULTS:
A total of 57 literatures were included,involving 66 cases,among which there were 15 new ADR. There were 34 male(51.52%)and 32 female(48.48%),with ratio of 1.061. Average age of patients was(63.4±10.5)years old. Sunitinib was mainly used for suprarenal epithelioma, accounting for 65.15%;followed by gastrointestinal stromal tumors, accounting for 21.21%. The incidence of ADR was the highest during 8-14 d(27.27%)and 22-28 d(22.73%)of medication. Organs/systems in-volved in ADR mostly were endocrine system(accounting for 25.76%). Main clinical manifestation was hypothyroidism,followed by diseases of skin and subcutaneous tissue(21.21%),diseases of the blood lymphatic system(16.67%)which mainly manifested as hand foot syndrome and thrombocytopenia (mainly being 4 degree bone marrow suppression). There were 9 cases of definite causal relationship and 57 cases of probable causal relationship. Fourteen cases of sunitinib-induced ADR were recovered after drug withdrawal(21.21%);27 cases were recovered after drug withdrawal and drug therapy(40.91%);17 cases had sequel after sur-gery,prolonging disease course and therapy (25.76%);there were 8 death cases (12.12%).CONCLUSIONS:
Sunitinib-induced ADR involve various organs/systems,and there are fatal cases. In the process of clinical medication,we should strengthen the ob-servation and monitoring,timely ADR disposal to guarantee the safety of patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Observational study
Language:
Chinese
Journal:
China Pharmacy
Year:
2017
Type:
Article
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