An application study on assessment for endometrial receptivity by detecting endom- etrial and sub-endometrial perfusion with contrast-enhanced ultrasound / 中国医学装备

ABSTRACT

Objective:To discuss the endometrial and sub-endometrial perfusion by using contrast-enhanced ultrasound (CEUS) so as to assess the clinical value of endometrial receptivity.Methods: 86 cases, that were divided into healthy group (49 healthy females) and infertility group (37 patients with infertility), were enrolled in the research. All of cases received detection of color doppler flow imaging (CDFI) and CEUS per vaginam at later period of proliferation, ovulatory period and window phase of implantation, respectively. In these cases, 20 healthy females and 18 patients received endometrial biopsy. The microvessel density (MVD) and time intensity curve (TIC) were analyzed.Results: At the later period of proliferation, the endometrial and sub-endometrial perfusion of the healthy females were significantly more abundant than that of the infertility females as the results of CDFI (x2=4.575,P<0.05). As the results of biopsy for later period of proliferation and ovulatory period, the endometrial MVD of infertility females were significantly lower than that of healthy females (t=7.821, t=8.659,P<0.05). As the results of CEUS for later period of proliferation and ovulatory period, the endometrial and sub-endometrial perfusion peak intensity (Pi) value and area under the curve (AUC) value of healthy females were significantly higher than that of infertility females (t=8.004,t=1.269,t=6.581,t=6.759,P<0.05). Besides, the sub-endometrial Pi were positive correlation with MVD at healthy group and infertility group, respectively.Conclusion:The CEUS can assess the endometrial receptivity through accurately detected endometrial and sub-endometrial perfusion. Therefore, it is worthy to be popularized in clinical practice.