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Investigation and Analysis of Off-label Use of Omeprazole in Outpatient Department of a Hospital / 中国药房
China Pharmacy ; (12): 4918-4921, 2017.
Article in Chinese | WPRIM | ID: wpr-664475
ABSTRACT

OBJECTIVE:

To investigate the omeprazole off-label use and provide reference for rational drug use in clinic.

METHODS:

In retrospective survey,1838 omeprazole prescriptions were selected from outpatient department during Jun. 2014 to May 2017 by random number table. According to the latest drug instruction,whether the off-label use or not was determined. Off-label use was determined by reviewing domestic and foreign guidelines,literatures and Micromedex database.

RESULTS:

Among 1838 pre-scriptions,there were 1750 prescriptions of off-label drug use (95.21%),involving 13 items and 3 types of off-label drug use. Main type of off-label drug use was over-indication medication,involving 1747 prescriptions (96.47%). There was no statistical significance in the incidence of off-label drug use between digestive department and non-digestive department or among physicians at different levels(P>0.05). Among 13 items of off-label drug use,7 items were supported by evidence-based medicine evidence of domestic and foreign guideline,expert consensus/suggestion or literature reports,etc.;among which 1 item of off-label drug use were included in Micromedex grading system and other 6 items had no evidence-based medicine evidence.

CONCLUSIONS:

The phenomenon of omeprazole off-label use is widespread in outpatient department of the hospital,and some off-label drug use are sup-ported by evidences. There are differences in the quality of those evidences. It is suggested to standardize the off-label drug use to avoid legal risks and guarantee the safety of drug use for patients.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline / Qualitative research Language: Chinese Journal: China Pharmacy Year: 2017 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline / Qualitative research Language: Chinese Journal: China Pharmacy Year: 2017 Type: Article