Glomus tumor:a clinicopathological analysis of 10 cases / 局解手术学杂志

ABSTRACT

Objective To study the clinicopathological characteristics ,diagnosis,differential diagnosis,therapy and prognosis of glomus tumor.Methods The clinical and histopathological features and immunohistochemical phenotypes were retrospectively analyzed in 10 cases of glomus tumors,with review of the related literature.Results Of 10 patients,6 cases were female,4 cases were male,mean age 45.3 years old.Glomus tumors commonly occurred in the end of fingers .We found that the shape of tumor was round or ovoid ,and the tumor exhibited grey red.The size of these tumors ranged from 0.4 cm to 2.7 cm in diameter.Microscopically,The tumor cells were uniform-sized,round or o-val,with clear or eosinophilic cytoplasm .The atypia and mitotic activity of these tumors were not observed .The tumor cells arranged around the thin-walled blood vessels showing a hemangiopericytoma-like pattern .Myxoid change was seen in the stroma of glomus tumor .The tumor cells expressed Vimentin ,SMA and collagen Ⅳby immunohistochemical staining ,but negative for CgA ,Syn,desmin,CD34,CK and S-100. All 10 cases were benign,and had no evidence of the recurrence in follow-up for 14 to 145 months.Conclusion Glomus tumor is a very rare soft tissue tumor ,and the atypical morphology of glomus tumors in unusual location may cause diagnostic difficulty .The diagnosis for glomus tumor depends mainly on histopathological features and immunohistochemical markers .