Study of Huaiqihuang particles in treatment of children with bron chialasthma and effect on immune function / 药物评价研究

ABSTRACT

Objective To investigate Huaiqihuang particles in treatment of children with bron chialasthma and effect on immune function.Methods 100 cases of children with bronchial asthma were randomly divided into control group and treatment group,50cases in each group,all were given routine western medicine treatment,and the treatment group combined with Huaiqihuang particles.The levels of interleukin-4 (IL-4),IL-5 and interferon gamma (IFN-γ),diurnal and nocturnal symptom scores before and after treatment and clinical efficacy and recurrence rate in followed up for 3 months in two groups were compared.Results After treatment,serum IL-4,IL-5 levels of the two groups were significantly decreased,IFN-γ levels were significantly increased in the same group before and after treatment,the difference was statistically significant (P ＜ 0.05).,serum IL-4 and IL-5 levels of treatment group were significantly lower than the control group,IFN-γ levels were significantly higher than the control group,there was statistically significant difference between groups (P ＜ 0.05).After treatment,daytime and nighttime symptom scores of two groups were significantly reduced than before treatment (P ＜ 0.05).And the treatment group was significantly lower than the control group (P ＜ 0.05).The total effective rate of the treatment group (96％) was significantly better than that of the control group (82％) (P ＜ 0.05).The treatment group recurred in 3 cases (6％),and the control group relapsed in 12 cases (24％).The recurrence rate of the treatment group was lower than that of the control group (P ＜ 0.05).Conclusion Huaiqihuang particles can effectively improve the immune function of patients with bron chialasthrna,enhance efficacy and reduce recurrence.