Influence of BNP and heart and kidney function of recombinant human brain natriuretic peptide on acute heart failure treatment / 药物评价研究

ABSTRACT

Objective To investigate the influence of BNP and heart and kidney function of recombinant human brain natriuretic peptide on acute heart failure treatment.Methods 120 cases from Jan.2011 to Dec.2016 in our hospital were chosen and randomly divided into two groups,the control group were given traditional treatment,the observation group were given brain natriuretic peptide on the basic of traditional treatment.The heart function,left ventricular ejection fraction,plasma BNP,urine output,serum creatinine,blood potassium concentration of two groups were compared.Results After 48 h,the total effective rate of the improvement of cardiac function in the observation group was 83.34％,which was significantly better than that of the control group 56.67％,the difference was statistically significant (P ＜ 0.05).After treatment,the heart function,left ventricular ejection fraction,plasma BNP,urine output of two groups after treatment were better than before treatment (P ＜ 0.05).And the heart function,LVEF ascending range,BNP concentration reduction and urine increased amount of observation group were better than control group (P ＜ 0.05).The serum creatinine concentration of two groups were slighter higher than before,the blood potassium concentration of observation group after treatment was slighter higher than before,the blood potassium concentration of control group was slighter lower than before,which had no significant difference,and after discontinuation which had no further intensified.Conclusion The recombinant human brain natriuretic peptide could be treating for acute heart failure treatment,and improve the heart function,decreased the plasma BNP level,dieresis and which had no adverse reaction on kidney function.