Comparison on clinical effect and safety of minocycline hydrochloride combined with metronidazole or tinidazole in treatment of chronic periodontitis / 药物评价研究

ABSTRACT

Objective To compare the clinical effect and safety of minocycline hydrochloride combined with metronidazole or tinidazole in treatment of chronic periodontitis.Methods Patients with chronic periodonitis (260 cases) accepted in Ninth Hospital of Xi'an from February 2014 to February 2016 were randomly divided into observation group and control group with 130 cases in each group.Patients in control group were given minocycline hydrochloride combined with metronidazole,and patients in observation group were given minocycline hydrochloride combined with tinidazole.Then the clinical effect,periodontal indexes and adverse reactions of two groups were compared.Results The total effective rate of observation group was 94.62％,which was obviously higher than that of control group (83.85％,P ＜ 0.05).The periodontal indexes of observation group were higher than control group (P ＜ 0.05).The adverse reaction rate of observation group was 8.46％,that of control group was 14.62％,which had no differences.The recurrence rate of observation group was 1.54％,that of control group was 6.92％,which had no differences.Conclusion Using minocycline hydrochloride combined with tinidazole has better effect in treatment of chronic periodontitis,which is safety and worthy of clinical application.